The UK Drug Administration and Health Products (MHRA) has issued a notice that urges women who use weight loss drugs such as Ozempic, Wegovy and Mounjaro to use effective contraception after multiple pregnancy reports between users, Guardian reported On June 5, 2025.
The notice follows 40 pregnancy reports to women taking these weight loss medicines, prompting MHRA to warn that Mounjaro, in particular, can reduce the effectiveness of oral contraceptives.
The body advises that women are receiving drug contraception that use drugs, such as condoms, in addition to oral contraceptives, according to The Guardian.
MHRA received 26 pregnancy -related reports about Mounjaro and additional eight reports associated with semiglutide -based drugs (Ozempic and Wegovy).
Another weight loss drug, Saxenda, which contains Liraglutide, also garnered nine reports.
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While it is not clear whether the pregnancies were unintentional, some women confirmed that their pregnancies were unplanned, as reported by the Guardian.
MHRA emphasized that these medicines should not be used during pregnancy or while trying to capture inadequate safety data about possible damage to a growing baby.
Women taking these drugs are also advised to continue contraception for up to two months after discontinuation of the drug before trying to become pregnant, as noted by the Health Service.
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Dr. Channa Jayasena, a consultant in reproductive endocrinology, noted that GLP-1 drugs such as Ozempic and Wegovy are effective to help weight loss, but could increase fertility in women with obesity by enhancing fertility.
However, these drugs may also interfere with the absorption of oral contraceptives, possibly increasing the risk of involuntary pregnancies. This was also highlighted in the Guardian’s cover.
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Dr. Alison Cave, MHRA’s head officer, urged patients not to use these weight loss medications, stressing that they are licensed for specific medical conditions and not for cosmetic purposes.
He also recommended that patients read the patient information brochures provided and consult health professionals before using these strong treatments, as mentioned in The Guardian.
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