In a major breakthrough, Chinese scientists have found a clinical cure for type 1 diabetes after performing a world-first islet cell transplant procedure on a female patient that reverses the major disease.
She was injected with stem cells harvested from her own body, according to clinical research published Wednesday in the journal Cellwhich also cited the Chinese doctors’ procedure as a possible clinical treatment for type 1 diabetes.
The first of its kind, stem cell therapy, was carried out by medical scientists from Tianjin First Central Hospital, Peking University, Changping Laboratory and Hangzhou Reprogenix Bioscience.
Type 1 diabetes is one of the more severe forms of the primary disease in which some people’s immune systems start attacking their pancreas as early as childhood, destroying the islet cells responsible for producing insulin.
Until now, any long-term treatment for the condition has been through a pancreas transplant, and in the short term most type 1 diabetes patients rely on insulin injections to control blood sugar.
Emerging studies over the past decade have pointed to a potential treatment using stem cells, which have the special ability to grow and differentiate into different types of cells. Independent United Kingdom was mentioned.
Scientists previously developed a revolutionary process in which a type of stem cell, which can be cultured and grow into any tissue, is used to replace tissues in the body.
The new medical trial, described in the journal last week, first involved extracting cells from a 25-year-old female patient from Tianjin, China, and returning them to their unspecialized state.
The patient, who had type 1 diabetes for 11 years, was completely dependent on insulin therapy and suffered from poor blood sugar control.
After transplanting islet cells derived from chemically induced pluripotent stem cells (CiPSC-islets), she regained the ability to autonomously regulate her blood sugar.
“Traditional islet transplant therapy can alleviate these problems,” Wang Shusen of Tianjin First Central Hospital, one of the paper’s corresponding authors, was quoted as saying by China’s state news agency. Xinhua.
Susen added that the treatment has shown clear progress as an alternative treatment strategy, but the lack of pancreas donors means its application is limited.
Seventy-five days after transplantation, she became insulin-independent and remained insulin-free for more than a year. All her diabetes-related markers have reached the levels of a healthy person, confirming the clinical cure of this patient with type 1 diabetes, the report added.
The researchers said the procedure “restored glycemic control” in the patient, functionally reversing type 1 diabetes within a year. They added that there was “no evidence of transplant-related abnormalities.”
However, the patient needed to be followed for a long time to validate the method’s effectiveness, the researchers cautioned. They added that the patient was already taking drugs to suppress her immunity due to a previous liver transplant.
The scientists also called for further clinical studies evaluating the benefits of stem cell transplantation in reversing type 1 diabetes.
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